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We performed detailed electrophysiologic studies on 16 patients with clinically defined multifocal motor neuropathy and found a wide spectrum of demyelinating features.Only 5 patients(31%)had conduction block in one or more nerves.However,in 15 patients(94%),at least one nerve showed other features of demyelination.We also noted a significant degree of superimposed axonal degeneration in 15 patients.Eight patients(50%)had individual nerves with pure axonal injury,despite the presence of demyelinating features in other nerves.Antiganglioside antibodies were elevated in 4 of 5 patients with conduction block and in 5 of 11 patients without conduction block.We conclude that multifocal motor neuropathy is characterized electrophysiologically by a wide spectrum of axonal and demyelinating features.Diagnostic criteria requiring conduction block may lead to underdiagnosis of this potentially treatable neuropathy. |
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conduction block
GM1 ganglioside antibodies
nerve conduction studies
neurologic disease,diagnoses of
neuropathy
neuropathy,motor
neuropathy,motor,multifocal
neuropathy,peripheral,treatment
neuropathy,work up for
treatment of neurologic disorder
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